HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-ethoxy-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid | HCID 33676677 | — |
| Product | 4-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride | HCID 86708158 | — |
Reaction Steps
D3 (43 mg, 0.17 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h at 67° C. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield D4. The crude material was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999982B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-087e8d4a4f25427b845d58d767064a5c |
| Source note | uspto-grants-2015_04 |