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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465191Generated: October 31, 2026

Bromomethylcyclopropane → Ethyl 4-(cyclopropylmethoxy)-1-(4-fluorophenyl)pyrazole-3-carboxylate

https://huagongshe.com/reaction/1465191

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromomethylcyclopropaneHCID 81503—
ReactantEthyl 1-(4-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylateHCID 730292—
ProductEthyl 4-(cyclopropylmethoxy)-1-(4-fluorophenyl)pyrazole-3-carboxylateHCID 66611660—

Reaction Steps

F1 was prepared from D1 following the general procedure reported in Preparative Example 16 Step 2 using (bromomethyl)cyclopropane for the alkylation. MS (ES) C16H17FN2O3 requires: 304. Found: 305 (M+H)+ and 327 (M+Na).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08999982B2
Source datasetuspto-grants-2015_04
ORD IDord-35082092a3eb4fd7b0b86c1c4e707a4b
Source noteuspto-grants-2015_04