1-Methyl-1H-pyrazole-3-carbonyl chloride → N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1-methyl-pyrazole-3-carboxamide

Participants

Reaction Steps

Q3 was prepared from 3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]aniline and 1-methyl-1H-pyrazole-3-carbonyl chloride following the general procedure reported in Preparative Example 1 Step 3. 1H NMR (400 MHz, d4-MeOD, 300K) δ 2.10 (m, 2H), 2.52 (m, 4H), 2.62 (t, J=7.5 Hz, 2H), 3.70 (t, J=4.7 Hz, 4H), 3.99 (s, 3H), 4.00 (s, 3H), 4.22 (t, J=6.2 Hz, 2H), 6.49 (d, J=5.4 Hz, 1H), 6.83 (d, J=2.3 Hz, 1H), 7.33 (m, 2H), 7.58 (d, J=8.8 Hz, 1H), 7.62 (s, 1H), 7.67 (d, J=2.4 Hz, 1H), 7.94 (dd, J=12.7 Hz, J=2.4 Hz, 1H), 8.40 (d, J=5.4 Hz, 1H). MS (ES) C28H30FN5O5 requires: 535. Found: 536 (M+H)+.

Provenance & Evidence