1-(3-Chloropropyl)-4-methylpiperazine → HCID 66771796, compound

Participants

Role	Name	HCID	Charge
Reactant	1-(3-Chloropropyl)-4-methylpiperazine	HCID 66906	—
Reactant	4-(2-Fluoro-4-nitrophenoxy)-7-hydroxy-6-methoxyquinoline	HCID 136175701	—
Product	HCID 66771796	HCID 66771796	—

Reaction Steps

S1 was prepared from 4-(2-fluoro-4-nitro-phenoxy)-6-methoxy-quinolin-7-ol and 1-(3-chloropropyl)-4-methylpiperazine following the general procedure reported in Preparative Example 54 Step 1-2. 1H NMR (400 MHz, d6-DMSO, 300K) δ 1.95 (quint., J=6.8 Hz, 2H), 2.14 (s, 3H), 2.22-2.47 (m, 10H), 3.94 (s, 3H), 4.17 (t, J=6.5 Hz, 2H), 5.48 (br.s, 2H), 6.38 (d, J=5.2 Hz, 1H), 6.46 (dd, J=8.7 Hz, J=2.4 Hz, 1H), 6.55 (dd, J=13.2 Hz, J=2.4 Hz, 1H), 7.07 (t, J=9.0 Hz, 1H), 7.36 (s, 1H), 7.50 (s, 1H), 8.44 (d, J=5.2 Hz, 1H). MS (ES) C24H29FN4O3 requires: 440. Found: 441 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08999982B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-b8aed40affe5432788747aaff62f7321
Source note	uspto-grants-2015_04