4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorobenzenamine → HCID 66612020, compound

HRID 1465207Notes

Reaction equation

HRID 1465207 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][C:17]=1[F:23].[CH2:24]([O:26][C:27]1[C:28]([C:41](Cl)=[O:42])=[N:29][N:30]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([N+:38]([O-:40])=[O:39])[CH:33]=2)[CH:31]=1)[CH3:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH:20][C:41]([C:28]2[C:27]([O:26][CH2:24][CH3:25])=[CH:31][N:30]([C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([N+:38]([O-:40])=[O:39])[CH:33]=3)[N:29]=2)=[O:42])=[CH:18][C:17]=1[F:23]

Participants

3

Reactant 2

HCID 114269974-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorobenzenamineHCID 86708161HCID 86708161, compound

Product 1

HCID 66612020HCID 66612020, compound

Procedure

Following the general procedure reported in Preparative Example 16 Step 5 X3 was prepared from A2 and 4-ethoxy-1-(3-nitrophenyl)-1H-pyrazole-3-carbonyl chloride, which was prepared similar to Preparative Example 16 step 1-4. MS (ES) C29H24N5O7 requires: 573. Found: 574 (M+H)+.

Workup

  1. customwas prepared similar

Sources & evidence

ORD record
ord-e5387227ae334c5f98f7e27db5b47b3a
Source dataset
uspto-grants-2015_04
Patent number
US08999982B2

Reaction notes

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