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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465338Generated: November 1, 2026

Potassium Hydroxide → 8-ethyl-5-(2-(4-(trifluoromethyl)-6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole

https://huagongshe.com/reaction/1465338

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant8-ethyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole 4-(trifluoromethyl)-2-methyl-5-vinylpyridineHCID 86691516—
SolventN-methyl-2-pyrrolidoneHCID 13387—
Product8-ethyl-5-(2-(4-(trifluoromethyl)-6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indoleHCID 57875903—

Reaction Steps

The title compound is prepared from a mixture of 8-ethyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole 4-(trifluoromethyl)-2-methyl-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08999978B2
Source datasetuspto-grants-2015_04
ORD IDord-e7c638c0b76247cf8f18e5223f206e1a
Source noteuspto-grants-2015_04