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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465346Generated: November 2, 2026

2-Methyl-5-vinylpyridine → 2,3,4,5-tetrahydro-2,6-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-1H-pyrido[4,3-b]indole

https://huagongshe.com/reaction/1465346

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-5-vinylpyridineHCID 8817—
ReactantPotassium HydroxideHCID 14797—
Reactant2,6-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoleHCID 593958—
SolventN-methyl-2-pyrrolidoneHCID 13387—
Product2,3,4,5-tetrahydro-2,6-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-1H-pyrido[4,3-b]indoleHCID 57875964—

Reaction Steps

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,6-dimethyl-1H-pyrido[4,3-b]indole, 2-methyl-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08999978B2
Source datasetuspto-grants-2015_04
ORD IDord-a2d720f23a754d4fa0d3cdcd3d7dd52b
Source noteuspto-grants-2015_04