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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465373Generated: November 1, 2026

Potassium Hydroxide → HCID 57875875, compound

https://huagongshe.com/reaction/1465373

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant8-chloro-2-methyl-1H,2H,3H,4H,5H-pyrido(4,3-b)indoleHCID 19615—
ReactantHCID 68735679HCID 68735679—
SolventN-methyl-2-pyrrolidoneHCID 13387—
ProductHCID 57875875HCID 57875875—

Reaction Steps

The title compound is prepared from a mixture of 8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, 1-methyl-4-vinylisoquinoline and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 10 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08999978B2
Source datasetuspto-grants-2015_04
ORD IDord-3f1363c7d22147e580d9d25b8f73099d
Source noteuspto-grants-2015_04