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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465383Generated: November 3, 2026

N-methyl-2-pyrrolidone → HCID 86691518, compound

https://huagongshe.com/reaction/1465383

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-methyl-2-pyrrolidoneHCID 13387—
ReactantPotassium HydroxideHCID 14797—
Reactant8-chloro-2-methyl-1H,2H,3H,4H,5H-pyrido(4,3-b)indoleHCID 19615—
ReactantHCID 68735601HCID 68735601—
ProductHCID 86691518HCID 86691518—

Reaction Steps

The title compound is prepared from: a mixture of 8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, N,N-dimethyl-5-vinylpyridin-2-amine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08999978B2
Source datasetuspto-grants-2015_04
ORD IDord-031eb16469d04d31a55b4620fae4be9c
Source noteuspto-grants-2015_04