反应详情

To a solution of 4-piperazinobenzofurano[3,2-d]pyrimidine (200 mg, 0.79 mmol) and pyridine (0.5 mL, 7.9 mmol) in dichloromethane (20 mL) was added a solution of product 1d in dichloromethane (20 mL) and this was stirred overnight. Methanol was added to quench excess thiophosgene; and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 150 mg (37%).

1. customto quench excess thiophosgene
2. customand the residue after removal of solvent
3. customwas purified by silica gel column chromatography
4. washeluting with 5% methanol/dichloromethane
5. customfurther recrystallized from dichloromethane/hexane
6. customto give 150 mg (37%)