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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465428Generated: October 31, 2026

Thionyl Chloride → 4-Chloro-6,7-dimethoxyquinazoline

https://huagongshe.com/reaction/1465428

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant6,7-Dimethoxy-3H-quinazolin-4-oneHCID 135495016—
SolventDimethylformamideHCID 6228—
Product4-Chloro-6,7-dimethoxyquinazolineHCID 2769364—

Reaction Steps

An analogous reaction to that described in Example 1, starting with 6,7-Dimethoxy-3H-quinazolin-4-one (31) reacted with thionylchloride in presence of DMF gave compound 32.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08999988B2
Source datasetuspto-grants-2015_04
ORD IDord-1be00eedc8fc403b915dc8b53b7e5067
Source noteuspto-grants-2015_04