反应详情

tert-Butyl 2-({4-[(4-acetamidophenyl)ethynyl]phenyl}acetyl)hydrazinecarboxylate (29 mg, 0.071 mmol) was dissolved in a mixture of tetrahydrofuran-methanol (1:1) and hydrogenated using a continuous hydrogenation reactor (trade name: H-CUBE, manufactured by ThalesNano) equipped with a 10%-palladium carbon cartridge. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (dichloromethane:methanol=97:3) to give tert-butyl 2-({4-[(4-acetamidophenyl)ethyl]phenyl}acetyl)hydrazinecarboxylate (24 mg, yield 82%).

1. concentrationThe reaction mixture was concentrated
2. customthe residue was purified by silica gel column chromatography (dichloromethane:methanol=97:3)