HRID1465439

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6326

Ethyne

C2H2

HCID58181284

未命名化合物

HCID67029623

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NNC(=O)Cc1ccc(C#Cc2csc(C3CCN(C(=O)OC(C)(C)C)CC3)n2)cc1

HCID58181310

未命名化合物

收率 18%

PROCEDURE

实验过程

Using tert-butyl 4-(4-ethynyl-1,3-thiazol-2-yl)piperidine-1-carboxylate and tert-butyl 2-[(4-bromophenyl)acetyl]hydrazinecarboxylate as starting materials, Sonogashira-Castero-Stephens acetylene coupling was performed under reaction conditions similar to those of Production Example 1, step 4 to give tert-butyl 4-[4-({4-[2-(tert-butoxycarbonyl)hydrazino]carbonylmethylphenyl}ethynyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (yield 18%).

WORKUP

后处理

customwas performed under reaction conditions similar to those of Production Example 1, step 4

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d321eac32acc44e9a19a67bc8a6dfba8
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08999989B2
来源说明: uspto-grants-2015_04

反应 SMILES

[C:1]([C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[S:6][CH:7]=1)#[CH:2].Br[C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]([NH:31][NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=[O:30])=[CH:24][CH:23]=1.C#C>>[C:36]([O:35][C:33]([NH:32][NH:31][C:29]([CH2:28][C:25]1[CH:24]=[CH:23][C:22]([C:2]#[C:1][C:3]2[N:4]=[C:5]([CH:8]3[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]3)[S:6][CH:7]=2)=[CH:27][CH:26]=1)=[O:30])=[O:34])([CH3:39])([CH3:37])[CH3:38]