1,4-Dioxane hydrochloride → HCID 67266296, compound

Participants

Reaction Steps

To a solution of tert-butyl 5-(4-iodophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (335 mg, 0.84 mmol) in anhydrous dioxane (3 ml) was added 4M-hydrogen chloride dioxane solution (4 ml, 16 mmol). After stirring at room temperature for 2 hrs, the mixture was concentrated under reduced pressure, dichloromethane was added and the mixture was concentrated again. The residue was washed with diethyl ether and dichloromethane, and dried to give 5-(4-iodophenyl) -2,5-diazabicyclo[2.2.1]heptane hydrochloride (272 mg, 96%) as a pale-green solid.

Provenance & Evidence