Sodium Hydroxide → HCID 86651841, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl [4-(2-{2-[(ethylsulfonyl)amino]-1,3-thiazol-4-yl}ethyl)phenyl]acetate (1.74 g, 4.72 mmol) in dioxane (17.4 ml) was added at 0° C. 1M aqueous sodium hydroxide solution (11.8 ml, 11.8 mmol), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was concentrated under reduced pressure, and water (20 ml) was added. After cooling to 0° C., 1M hydrochloric acid (16 ml) was added dropwise with stirring. After stirring at 0° C. for 30 mins, the precipitate was collected by filtration, washed with water and dried under reduced pressure to give [4-(2-{2-[(ethylsulfonyl)amino]-1,3-thiazol-4-yl}ethyl)phenyl]acetic acid (1.66 g, yield 99%).

Provenance & Evidence