Hydrochloric Acid → HCID 67030533, compound

Participants

Reaction Steps

To a solution of methyl 5-{2-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]ethyl}thiophene-2-carboxylate (550.0 mg, 1.473 mmol) in dioxane (4.5 ml) were added 1M aqueous sodium hydroxide solution (5.15 ml, 5.15 mmol) and water (2.2 ml) at 0° C. After stirring at room temperature for 1 hr, the mixture was cooled to 0° C., and 1M hydrochloric acid (8.84 ml, 8.84 mmol) was added. The mixture was concentrated to dryness to give crude 5-{2-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]ethyl}thiophene-2-carboxylic acid hydrochloride as a pale-yellow solid.

Provenance & Evidence