1,4-Dioxane hydrochloride → HCID 67030612, compound

Participants

Reaction Steps

By a method similar to Production Example 115, step 5, tert-butyl 2-{[2-(5-{2-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]ethyl}thiophen-2-yl)ethyl]carbamoyl}hydrazinecarboxylate (498.0 mg, 0.964 mmol) was deprotected with 4M hydrogen chloride dioxane solution. The crude product was purified by aminopropylated silica gel and recrystallized from dichloromethane-methanol to give the title compound (170.8 mg, yield 42.5%) as a slightly yellow white solid.

Provenance & Evidence