Hydrochloric Acid → HCID 53259487, compound

Participants

Reaction Conditions

Reaction Steps

4-[1-(3-Fluorophenyl)-1-methoxymethoxyethyl]-6-[2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]pyrimidin-2-ylamine (234 mg, 0.25 mmol) is dissolved in MeOH (10 ml), 25% HCl (1 ml, 5.14 mmol) is added, and the mixture is stirred at 50° C. for about 1.5 h. The solvent is evaporated in vacuo. The residue is purified by HPLC on RP-18e, giving 1-{2-amino-6-[2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol (“A3”); (HPLC/MS Rt=1.53 min, [M+H] 431);

Provenance & Evidence