3-Fluorobenzoyl chloride → 1'-{[6-Chloro-1-(3-fluorobenzoyl)-1H-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

HRID 146557Notes

Reaction equation

HRID 146557 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][C:18](=[O:26])[c:19]5[c:20]4[cH:21][cH:22][c:23]([F:25])[cH:24]5)[CH2:27][CH2:28]3)[cH:7][nH:8][c:9]2[cH:10]1.[F:29][c:30]1[cH:31][c:32]([C:33](=[O:34])[Cl:35])[cH:36][cH:37][cH:38]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][C:18](=[O:26])[c:19]5[c:20]4[cH:21][cH:22][c:23]([F:25])[cH:24]5)[CH2:27][CH2:28]3)[cH:7][n:8]([C:33]([c:32]3[cH:31][c:30]([F:29])[cH:38][cH:37][cH:36]3)=[O:34])[c:9]2[cH:10]1

Participants

3

Reactant 2

HCID 743763-Fluorobenzoyl chlorideHCID 596576231'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 596577141'-{[6-Chloro-1-(3-fluorobenzoyl)-1H-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Sources & evidence

ORD record
ord-c0b61293b57e4391bf5eb5ff9a8f209c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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