Thiourea → HCID 86690885, compound

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Reaction Steps

A mixture of 2-bromo-1-(2-fluoro-4-(4-methoxyphenoxy)-6-methylphenyl)ethanone (30-6, 0.60 g) and thiourea (0.160 mg, 2.05 mmol) in 95% EtOH (12.0 mL) was heated at reflux for 60 min. The solution was concentrated under reduced pressure, and the residue was re-dissolved in ethyl acetate. The solution was washed with saturated aqueous NaHCO3, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to give 4-(2-fluoro-4-(4-methoxyphenoxy)-6-methylphenyl)thiazol-2-ylamine (30-7, 0.450 g, 1.36 mmol) as yellow solids in 80% yield: 1H NMR (500 MHz, CDCl3) δ 6.98 (d, J=9.0 Hz, 2 H), 6.89 (d, J=9.0 Hz, 2 H), 6.60 (s, 1 H), 6.49 (d, J=10.9 Hz, 1 H), 6.41 (s, 0.1 H), 3.80 (d, J=3.4 Hz, 3 H), 2.26 (s, 3H). ESI-MS: m/z 331.0 (M+H)+.

Provenance & Evidence