HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465682Generated: October 30, 2026
Potassium Carbonate → tert-butyl (3S)-3-ethynylpiperidine-1-carboxylate
https://huagongshe.com/reaction/1465682
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl (3R)-3-formylpiperidine-1-carboxylate | HCID 42325667 | — |
| Reactant | (1E)-1-diazo-1-dimethoxyphosphorylpropan-2-one | HCID 136023029 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-butyl (3S)-3-ethynylpiperidine-1-carboxylate | HCID 52420760 | — |
Reaction Steps
To crude (R)-tert-butyl 3-formylpiperidine-1-carboxylate in MeOH (20 mL) was added dimethyl 1-diazo-2-oxopropylphosphonate (1.28 g, 5.6 mmol), cooled to 0° C. and then added K2CO3 (2.56 g, 18.6 mmol), followed by MS, TLC. Added water (60 mL), extracted with EtOAc (3×50 mL), organic layer were evaporated and dried to give the desired product (S)-tert-butyl 3-ethynylpiperidine-1-carboxylate (0.86 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08999966B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-439e4a2809d0414295308e1c0b251c21 |
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| Source note | uspto-grants-2015_04 |
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