Iodine → HCID 178419333, compound

Participants

Reaction Steps

To a solution of 5-bromo-1H-indazole (8.00 g, 40.6 mmol) in DMF (200 ml), was added I2 (20.61 g, 81.2 mmol) and KOH (8.54 g, 152.3 mmol) successively. The reaction was stirred at room temperature for 3 h. The mixture was then poured into aqueous NaHSO3 and extracted with Et2O (3×150 ml). The combined organic layers were washed with water (3×150 ml) and brine (3×150 ml). It was dried over anhydrous Na2SO4 and evaporated to dryness to give crude product 5-bromo-3-iodo-1H-indazole (17.21 g).

Provenance & Evidence