HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (R)-5-(1-(piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-tert-butyl 5-(1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole-1-carboxylate | HCID 86695575 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-5-(1-(piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole | HCID 86695576 | — |
Reaction Steps
To the crude (R)-tert-butyl 5-(1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole-1-carboxylate in CH2Cl2 (40 mL), added TFA (2.5 mL) and stirred at room temperature overnight under a stream of nitrogen. Evaporated the solvents and column purified (5-10% MeOH in CH2Cl2) to give (R)-5-(1-(piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole (0.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999966B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-85c8c2cc2036400ebcb01c14259069d8 |
| Source note | uspto-grants-2015_04 |