2,6-Difluorobenzaldehyde → (R)-5-(1-(1-(2-fluoro-6-methylbenzyl)piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole

Participants

Reaction Steps

(R)-5-(1-(piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole (0.05 g, 0.14 mmol) was dissolved in MeOH (3 mL) at 0° C., added 2,6-difluorobenzaldehyde (0.2 g, 1.4 mmol) and then sodium triacetoxyborohydride (0.0761 g, 0.37 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 3 h. Evaporated the solvent, subjected to Preparative Thin Layer chromatography to give (R)-5-(1-(1-(2-fluoro-6-methylbenzyl)piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole (0.034 g).

Provenance & Evidence