Hydrazine → (R)-1-Boc-piperidine-3-carboxylic acid hydrazide

Participants

Reaction Steps

Stirred a solution of (R)-1-tert-butyl 3-ethyl piperidine-1,3-dicarboxylate (5 g, 19.4 mmol), hydrazine (anhydrous; 2 ml) in MeOH (5 ml) in a microwave oven at 100° C. for 3 hours. Cooled and solvent was evaporated. Chromatographed residue on silica gel eluting with 3% MeOH: DCM to yield (R)-tert-butyl 3-(hydrazinecarbonyl)piperidine-1-carboxylate as colorless oil (5.1 g).

Provenance & Evidence