2-Fluoro-6-methoxybenzaldehyde → HCID 67517547, compound

Participants

Reaction Steps

Added 2-Fluoro-6-methoxy benzaldehyde (69 mg, 0.44 mmol) to a mixture of (R)-5-(5-(piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole (96 mg, 0.277 mmol) and sodium triacetoxy borohydride (176 mg, 0.833 mmol) in MeOH (8 ml) at room temperature. After stirred for 30 minutes, the solvent was evaporated. Diluted with EtOAc (150 ml), washed with H2O (50 ml), dried (Na2SO4) and concentrated. Crude product was purified on silica gel eluting with 5% v/v MeOH/CH2Cl2 to yield (R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole as a white solid (54 mg).

Provenance & Evidence