Methanol → HCID 67518126, compound

Participants

Reaction Conditions

Reaction Steps

Added 2-chloro-1-(piperidin-1-yl)ethanone (50 mg, 0.31 mmol) to a solution of (R)-5-(5-(-(piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole (47 mg, 0.106 mmol) and triethylamine (0.3 ml, 2.1 mmol) in MeOH (10 ml). After stirred at 50° C. overnight, reaction mixture was concentrated then purified on preparative TLC (20×20 cm) eluting with 10% v/v MeOH/MeCl2 saturated with NH4OH to yield (R)-1-(piperidin-1-yl)-2-(3-(3-(3-(pyridin-4-yl)-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidin-1-yl)ethanone as a white solid (23 mg).

Provenance & Evidence