Triethylamine → HCID 178481728, compound

Participants

Reaction Conditions

Reaction Steps

Added triethylamine (0.5 ml, 3.59 mmol) to a solution of ethyl 3-bromo-1H-indazole-5-carbimidate hydrochloride (200 mg, 0.658 mmol) and (R)-tert-butyl 3-(2-methylhydrazine-carbonyl)piperidine-1-carboxylate (200 mg, 0.78 mmol) in EtOH (USP, 5 ml) and heated in a microwave oven at 100° C. for 12 hours. Evaporated solvent then chromatographed residue on silica gel eluting with 1/1 v/v EtOAc/Hexanes to yield (R)-tert-butyl 3-(3-(3-bromo-1H-indazol-5-yl)-1-methyl-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate as a white solid (100 mg).

Provenance & Evidence