Cesium carbonate → (R)-tert-butyl 3-(1-methyl-3-(3-(pyridin-4-yl)-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

Participants

Reaction Steps

Stirred a mixture of (R)-tert-butyl 3-(3-(3-bromo-1H-indazol-5-yl)-1-methyl-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate (50 mg, 0.0108 mmol), 4-pyridyl boronic acid (50 mg, 0.409 mmol), PdCl2dppf (10 mg, 0.0136 mmol), cesium carbonate (60 mg, 0.1846 mmol) in dioxane/H2O (v/v 3/1, 4 ml) at 100° C. in a microwave oven for 2 hours. Reaction was cooled, extracted with DCM (50 ml), washed with H2O (20 ml). Dried (Na2SO4), filtered and solvent evaporated to yield (R)-tert-butyl 3-(1-methyl-3-(3-(pyridin-4-yl)-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate as a white solid (30 mg).

Provenance & Evidence