Trifluoroacetic acid → tert-butyl 3-(1-(3-(pyridin-4-yl)-1H-indazol-5-yl)-1H-pyrazol-3-yl)piperidine-1-carboxylate

Participants

Reaction Steps

To tert-butyl 3-(1-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-pyrazol-3-yl)piperidine-1-carboxylate (140 mg, 0.2 mmol) in DCM (5 mL) were added triethylsilane (40 mg, 0.34 mmol) and trifluoroacetic acid (1 mL), the reaction mixture was stirred at room temperature for 3 h. After concentration, crude mixture was column purified with mixture of methanol, dichloromethane and ammonia to give tert-butyl 3-(1-(3-(pyridin-4-yl)-1H-indazol-5-yl)-1H-pyrazol-3-yl)piperidine-1-carboxylate (120 mg).

Provenance & Evidence