Potassium Phosphate, Tribasic → HCID 67518058, compound

Participants

Reaction Conditions

Reaction Steps

To tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate (0.66 g, 2 mmol) and 3-(pyridin-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-indazole (1.13 g, 2 mmol) in dioxane (8 mL) and water (2 mL) was added potassium phosphate (848 mg, 4 mmol) and PdCl2(dppf) (120 mg, 0.16 mmol). The reaction mixture was stirred at 80° C. for 24 h. After filtered through a pad of celite, and washed with EtOAc, the filtrate was washed with brine, dried and concentrated. The crude mixture was column purified with mixture of methanol, dichloromethane and ammonia to give tert-butyl 3-(4-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (420 mg) as light yellow solid.

Provenance & Evidence