HCID 86695586, compound → HCID 86695587, compound

Participants

Reaction Steps

(1S,5R)-8-tert-butyl 2-methyl 8-azabicyclo[3.2.1]oct-2-ene-2,8-dicarboxylate (5.45 g) was dissolved in ethanol (200 mL), Palladium hydroxide (20% wt, 2.73 g) was added. After vacuum degassed, the reaction mixture was hydrogenated under hydrogen balloon overnight. After filter through a pad of celite, washed with ethanol, the filtrate was concentrated to give 5.49 g of crude product. The crude was brought to next step without further purification.

Provenance & Evidence