Pyridine → HCID 67517760, compound

Participants

Reaction Conditions

Reaction Steps

To N′-(8-(2-fluorobenzyl)-8-azabicyclo[3.2.1]octane-2-carbonyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carbohydrazide (142 mg, 0.19 mmol) in acetonitrile (1.6 mL) was added pyridine (44 mg, 0.56 mmol), followed by phosphoryl trichloride (86 mg, 0.56 mmol). The reaction mixture was heated at 100° C. under microwave condition for 30 min. After quench with saturated NaHCO3, the mixture was extracted with EtOAc. The combined organic layer was dried and concentrated to give 40 mg crude product. The crude was brought to next step without further purification.

Provenance & Evidence