HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-methoxypyridine-3-carboxylate → Methyl 5-methoxypiperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-methoxypyridine-3-carboxylate | HCID 16218325 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 5-methoxypiperidine-3-carboxylate | HCID 67033617 | — |
Reaction Steps
Methyl 5-methoxypyridine 3-carboxylate (1 g, 6.02 mmol) and platinum (IV) oxide (50 mg) suspended in 1.25 M HCl in methyl alcohol (10 mL) were hydrogenated in Parr shaker under 40 psi overnight. The reaction mixture was filtered through a pad of celite, washed with MeOH and concentrated to give crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999966B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-b08db43995ce49609d6a0676ce25b091 |
| Source note | uspto-grants-2015_04 |