2-Fluoro-6-methoxybenzaldehyde → HCID 67515938, compound

Participants

Reaction Steps

To Methyl 5-methoxypiperidine-3-carboxylate (500 mg, 2.9 mmol) in DCM (10 mL) was added 2-fluoro-6-methoxybenzaldehyde (890 mg, 5.8 mmol) and 10 drops of acetic acid. After stirring for 15 min, sodium triacetoxyborohydride (2.4 g, 11.6 mmol) was added. The reaction mixture was stirred at room temperature overnight. After quench with saturated Na2CO3, the mixture was extracted with DCM. Dried and concentrated to give crude product.

Provenance & Evidence