Potassium Phosphate, Tribasic → HCID 89525197, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	1-N,2-N-dimethylcyclohexane-1,2-diamine	HCID 551074	—
Reactant	2,6-Dibromonaphthalene	HCID 640591	—
Reactant	Tert-butyl 3-oxopiperazine-1-carboxylate	HCID 3157178	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Solvent	Ethyl Acetate	HCID 8857	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 89525197	HCID 89525197	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

To a microwave tube charged with a stir bar was added 2,6-dibromonaphthalene (710 mg, 2.5 mmol), tert-butyl 3-oxopiperazine-1-carboxylate (250 mg, 1.2 mmol), copper(I) iodide (48 mg, 0.25 mmol), N,N′-dimethylcyclohexane-1,2-diamine (71 mg, 0.50 mmol), K3PO4 (530 mg, 2.5 mmol), and dioxane (10 mL). The mixture was heated to 150° C. in a microwave reactor for 1 hour. The reaction was diluted with EtOAc, adsorbed onto silica gel, and purified by MPLC (silica gel, EtOAc-Hexanes) to afford the title compound. LC-MS (IE, m/z): 407 [M+1]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08999991B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-00560ec4cfeb46d6b7f7d49a038e2542
Source note	uspto-grants-2015_04