HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 89525256, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-Piperazinecarboxylic acid, 4-(3-cyano-7-quinolinyl)-3-oxo-, 1,1-dimethylethyl ester | HCID 89526506 | — |
| Product | HCID 89525256 | HCID 89525256 | — |
Reaction Steps
tert-Butyl 4-(3-cyanoquinolin-7-yl)-3-oxopiperazine-1-carboxylate was treated with TFA (2 mL) for 20 minutes at RT. The TFA was removed under vacuum, and the residue was dissolved in aqueous sodium carbonate, extracted with DCM, dried over sodium sulfate, and concentrated to deliver the free base of 7-(2-oxopiperazin-1-yl)quinoline-3-carbonitrile. LC-MS (IE, m/z): 253 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999991B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-a77b3b0b9ba04494aa91305013cc5217 |
| Source note | uspto-grants-2015_04 |