反应详情

温度

145 °C

A mixture of 4-Methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one (0.46 g, 2.4 mmol) and piperazin-2-one (0.20 g, 2.0 mmol) was heated to 145° C. in a microwave tube for 1 hour. The crude reaction was diluted with DCM, adsorbed onto silica gel, and purified by silica gel chromatography to provide the title product. LC-MS (IE, m/z): 291 (M+1)+.

1. customThe crude reaction
2. custompurified by silica gel chromatography