6-Chloro-2-iodothieno[2,3-b]pyridine → 6-Chlorothieno[2,3-b]pyridine-2-carbonitrile

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-Chloro-2-iodothieno[2,3-b]pyridine (80 mg, 0.27 mmol) and Copper (I) Cyanide (36 mg, 0.41 mmol) in DMF (3 mL) was heated to 130° C. for 16 hrs. LC showed formation of the title product. The crude reaction was adsorbed onto silica gel, and purified by flash chromatography to obtain the title product. LC-MS (IE, m/z): 195 [M+1]+.

Provenance & Evidence