Allyltributylstannane → 4-methyl-5-prop-2-en-1-yl-2-benzofuran-1(3H)-one

Participants

Reaction Steps

To a flask charged with 5-Bromo-4-methyl-2-benzofuran-1(3H)-one (320 mg, 1.41 mmol) and a stir bar was added Allyl tri-n-butyltin (0.655 ml, 2.11 mmol), Pd(PPh3)4 (244 mg, 0.211 mmol), lithium chloride (179 mg, 4.23 mmol), and toluene (15 mL). The reaction was purged with nitrogen 2 times then was heated at reflux for 4 hours. The product was purified by silica gel chromatography to give the title compound.

Provenance & Evidence