4-Methyl-5-((2R)-oxiran-2-yl)-2-benzofuran-1(3H)-one → HCID 89535521, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(2-oxopiperazin-1-yl)isoquinoline-7-carbonitrile [I-6] (20 mg, 0.079 mmol) and 4-methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one (30 mg, 0.16 mmol) in EtOH (1 mL) in a 5 mL microwave tube was heated to 145° C. for 1.5 hours. LC showed formation of title product, which was purified by mass-directed reverse phase HPLC (AcCN-Water with 0.1% TFA). LC-MS (IE, m/z): 443 [M+1]+.

Provenance & Evidence