4-Methyl-5-((2R)-oxiran-2-yl)-2-benzofuran-1(3H)-one → HCID 89535477, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-(2-oxopiperazin-1-yl)naphthalene-2-carbonitrile [I-7] (35 mg, 0.14 mmol) and 4-methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one (40 mg, 0.21 mmol) in EtOH (2 mL) in a 5 mL microwave tube was heated to 145° C. for 2 hours. LC showed formation of the title product, which was purified by silica gel flash chromatography. LC-MS (IE, m/z): 442 [M+1]+.

Provenance & Evidence