4-Methyl-5-((2R)-oxiran-2-yl)-2-benzofuran-1(3H)-one → HCID 71519591, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-Oxopiperazin-1-yl)-1,3-benzothiazole-5-carbonitrile [I-8] (25 mg, 0.10 mmol) and 4-methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one (37 mg, 0.19 mmol) in EtOH (2 mL) in a 5 mL microwave tube was heated to 145° C. for 1.5 hours. LC showed formation of the title product, which was purified by silica gel flash chromatography. LC-MS (IE, m/z): 449 [M+1]+.

Provenance & Evidence