4-Methyl-5-((2R)-oxiran-2-yl)-2-benzofuran-1(3H)-one → HCID 89535494, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-(2-oxopiperazin-1-yl)quinoline-3-carbonitrile [I-9] (20 mg, 0.079 mmol) and 4-methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one (30 mg, 0.16 mmol) in EtOH (1.5 mL) in a 5 mL microwave tube was heated to 140° C. for 2 hours. LC showed formation of the title product, which was purified by mass-directed reverse phase HPLC (AcCN-Water with 0.1% TFA). LC-MS (IE, m/z): 443 [M+1]+.

Provenance & Evidence