反应详情

To a solution of ethyl 4-amino-2-methoxy-5-nitrobenzoate (248 mg, 1.03 mmol) in methanol (20 ml) was added 5% palladium on activated carbon (85 mg) and the mixture stirred vigorously at room temperature under a hydrogen atmosphere for 18 h. The reaction mixture was then filtered through celite, the catalyst/residue washed with methanol and the combined filtrate and washings concentrated to give crude ethyl 4,5-diamino-2-methoxybenzoate (220 mg, 100%) as a dark-brown material, which was used in the next step without further purification.

1. filtrationThe reaction mixture was then filtered through celite
2. washthe catalyst/residue washed with methanol
3. concentrationthe combined filtrate and washings concentrated