HCID 178495816, compound → HCID 178495815, compound

Participants

Reaction Steps

To a solution of 4-{5-[4-(2-methoxy-ethyl)-piperazin-1-yl]-1H-benzoimidazol-2-yl}-2-nitro-phenylamine (0.5 g, 1.2 mmol) in 4:1 ethyl acetate/methanol (60 ml) under nitrogen, was added 5% palladium on carbon (100 mg) and the mixture was first evacuated and then stirred at room temperature under an atmosphere of hydrogen for 1 day. The reaction mixture was then filtered through Celite, washed with 1:1 ethyl acetate/methanol (10 mL) and the combined filtrate and washings were concentrated to give the crude 4-{5-[4-(2-methoxy-ethyl)-piperazin-1-yl]-1H-benzoimidazol-2-yl}-benzene-1,2-diamine as a thick oil that was used in the next step without any purification.

Provenance & Evidence