HCID 9899728, compound → HCID 86682382, compound

Participants

Reaction Steps

To a solution of 5-(cis-2′,6′-dimethylmorpholino)-2-nitroaniline (1.26 g, 5.03 mmol) in 4:1 ethyl acetate/methanol (75 ml) was added 5% palladium on carbon (0.24 g) and the reaction mixture stirred under an atmosphere of hydrogen for 25 h. The reaction mixture was then filtered through celite, the filtered solid washed with methanol, and the combined filtrate and washings concentrated in vacuo to give crude 2-amino-4-(cis-2′,6′-dimethylmorpholino)aniline (1.08 g, 97%) which was used immediately in the next step.

Provenance & Evidence