Acetamide → HCID 136351380, compound

HRID 1465913Notes

Reaction equation

HRID 1465913 reaction equation
[NH:1]1[C:10]2[C:5]([CH:6]=[CH:7][C:8]3[C:9]=2[CH:11]=[CH:12][N:13]=3)=[CH:4][CH:3]=[C:2]1[C:14](=O)[C:15]([O:17]C)=O.[C:20]([NH2:23])(=[O:22])[CH3:21]>>[NH:1]1[C:10]2[C:5]([CH:6]=[CH:7][C:8]3[C:9]=2[CH:11]=[CH:12][N:13]=3)=[CH:4][CH:3]=[C:2]1[C:14]1[C:15](=[O:17])[NH:23][C:20](=[O:22])[CH:21]=1

Participants

3

Reactant 2

HCID 178Acetamide2×HCID 136378698HCID 136378698, compound2×

Product 1

HCID 136351380HCID 136351380, compound

Procedure

In one embodiment, the method of the present invention comprises a step of dissolving methyl pyrroloquinolinyl-oxoacetate and acetamide in an organic solvent and adding the obtained solution to a base, and reacting methylpyrroloquinolinyl-oxoacetate and acetamide to form highly pure pyrroloquinolinyl-pyrrole-2,5-dione. In one embodiment, the base is dissolved or suspended in an organic solvent. In a further embodiment, the base is dissolved or suspended in the same organic solvent as methylpyrroloquinolinyl-oxoacetate and acetamide. In a further embodiment, highly pure pyrroloquinolinyl-pyrrolidine-2,5-dione is formed by reducing pyrroloquinolinyl-pyrrole-2,5-dione.

Workup

  1. additionadding the obtained solution to a base

Sources & evidence

ORD record
ord-ec733e091a8d49519434a14d89045e54
Source dataset
uspto-grants-2015_04
Patent number
US09000005B2

Reaction notes

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