HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → methyl 2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-oxoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-Azatricyclo[6.3.1.0,4,12]dodeca-2,4,6,8(12)-tetraene | HCID 15645629 | — |
| Product | methyl 2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-oxoacetate | HCID 59298805 | — |
Reaction Steps
In one aspect, Step 1 is the reaction of lilolidine with oxalyl chloride in an inert solvent and methanol to form compound C. In one aspect, the amount of oxalyl chloride used with respect to lilolidine is about 1.0 to about 1.2 equivalents. In another aspect, the amount of oxalyl chloride to lilolidine is about 1.05 equivalents.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09000005B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-9f20389f91e94e61b98bff6fcbd2010a |
| Source note | uspto-grants-2015_04 |