Glycine → HCID 11695634, compound

Participants

Reaction Steps

2-Bromo-4-hydroxy-thieno[2,3-c]pyridine-5-carboxylic acid butyl ester (7 mg, 0.020 mmol, example 1.g) and glycine (38 mg, 0.5 mmol) were suspended in 1 mL of 0.5 N sodium methoxide in methanol. The resultant mixture was heated to 120° C. for 10 min. using a CEM microwave reactor. The reaction mixture was cooled, concentrated to ca. 0.2 mL under high vacuum, and diluted with 1 mL of 1.0 N HCl. The resultant precipitate was collected on a fine glass filter funnel, washed twice with water, and dried under hi-vacuum to yield 7 mg of the title compound. MS: (−) m/z 328.98, 331.03 (M−1, 79Br/81Br)

Provenance & Evidence